Colorado family fights for access to lifesaving drug for infant with Barth syndrome

By Karen Morfitt

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    COLORADO (KCNC) — A Colorado family is in a race against time to secure access to an experimental drug that’s keeping their infant son alive.

Gilbert Dryden was born with Barth syndrome — an ultra-rare genetic condition that affects only one in 300,000 births, almost exclusively boys.

The disease compromises the mitochondria — the energy-producing structures in nearly every cell — and can lead to heart failure, even in infancy.

For Gilbert’s mom Madison Dryden, the condition is one she feared. Her brother, Ben, died from heart failure as a baby — a tragedy that left the family without answers for decades.

“His heart basically turned … it was turning into scar tissue, kind of like turning into stone,” Madison’s mother, Jeanne Eiss said, “There was nothing we could do.”

When Gilbert was admitted to the NICU shortly after birth, Madison’s thoughts went immediately to her late brother.

“Once we were admitted to the NICU, that was immediately where my mind went — to my brother Ben,” said Madison Dryden.

“I think it would be worse for her because she has hope,” Eiss said through tears as she thought back to losing her son.

At Children’s Hospital Colorado, pediatric cardiologist Dr. Kathryn Chatfield helped identify Gilbert’s condition.

“It’s so rare that in any given state there may be only one or two patients diagnosed,” Chatfield said. “When the mitochondria can’t produce enough energy, the heart muscle weakens. If that dysfunction progresses, the heart can fail — and ultimately, patients may die or require a transplant.”

The drug, elamipretide, is not yet FDA approved. But for critically ill patients like Gilbert, the FDA has made it available under emergency use authorization.

Dr. Brian Stauffer, a cardiologist and researcher at the University of Colorado Anschutz Medical Campus, worked with Chatfield and others on initial research into the drug starting in 2015.

“When we treated hearts with elamipretide, we saw significant improvement in mitochondrial function. More energy production, which we believe improves heart function,” said Stauffer.

For the Dryden family, the results were immediate and dramatic.

“Within a month of being on elamipretide, he got his NG tube out. The next month, he came home,” Madison said.

Despite a recommendation from an FDA advisory panel last October, final approval was delayed and then rejected in May. The agency cited the small trial size — and requested more data.

“We don’t have the luxury of waiting many more months or years,” said Chatfield. “Companies must eventually turn a profit to stay in business. If this stalls too long, they may have to stop production entirely.”

Rep. Jason Crow, who represents Colorado’s 6th Congressional District, is now leading a bipartisan push for action, with almost all of Colorado’s congressional delegation signing on to a letter urging the FDA to make a timely decision.

“If this is the only drug keeping your child alive — give people the damn drug,” Crow said in a Zoom interview. “We understand there’s a process, but make government work.”

In August, the FDA agreed to reconsider and a new drug application was resubmitted under an accelerated pathway. A final decision is now expected Sept. 26.

In the meantime, the Dryden family is counting every remaining vial in their refrigerator.

“We get a three-month supply,” Madison said. “We are talking end of October.”

“We had to sit down with our daughters and say: ‘We’re working hard on this because if Gilbert doesn’t get his medicine, his heart might stop working. And if his heart stops working, he will die,'” she said.

The FDA did not respond to a request for comment when contacted for this story. CBS Colorado will provide updates as more information becomes available.

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Lake Tahoe neighbors protest California plan to euthanize mother bear Hope after home break-ins

By Ashley Sharp

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    LAKE TAHOE, California (KPIX) — A mother black bear and her cub are causing quite the stir in South Lake Tahoe, as some neighbors are now rallying community support for the duo.

It comes as the California Department of Fish and Wildlife confirmed to CBS Sacramento on Wednesday that they are monitoring the bears and plan to euthanize the mother, which is identified by its tag number as bear number 753.

“CDFW had determined that the bear is ‘habituated’ – meaning it has learned to associate people, homes and neighborhoods as sources of food and has become completely reliant and dependent on those human food sources. Consequently, CDFW has determined that management action is required, and bear 753 has been approved for lethal removal,” a spokesperson for the agency told CBS Sacramento in a statement.

On both Tuesday and Wednesday evenings, Tahoe’s nonprofit BEAR League and south shore neighbors teamed up to call attention to the plans and send a message that bears should not be killed. They hosted a roadside protest near the Tahoe Keys Marina.

The Tahoe community has lovingly named the mother, Hope, and her playful cub, Bounce.

“We want to evolve. We want to coexist,” said Staci Baker at the roadside rally Wednesday night.

Baker is a veterinarian of 30 years in the greater Tahoe region.

“We can be kinder and smarter. We can do this as a community. We don’t want CDFW trapping and slaughtering anymore,” Baker said.

The CDFW said the approved “lethal removal” follows a series of more than a dozen home break-ins by the bears this summer.

“This sow and now its dependent cub have repeatedly broken into homes, including occupied homes and including situations that were no fault of the property owners. Obviously, this creates an unsafe situation when an adult bear is actively looking to break into homes and other buildings. From our long experience in the Tahoe Basin and other parts of the state, this conflict behavior is likely to continue and escalate over time as the bears persist in seeking out human food sources. While this bear has not shown aggressive behavior toward people, that is too often the outcome in situations such as this, once a bear has lost its natural fear of people,” a spokesperson for the agency told CBS Sacramento.

Kathi Zollinger, a volunteer team leader for the BEAR League, says she has been working round-the-clock daily to humanely ‘haze’ the bears with paintball guns, vehicles and other non-lethal options to help push the bears back to the wild where they belong.

“People call and we will go haze her out of mainly the keys, sometimes up to 9 hours a day,” said Zollinger, describing the work as a full-time job.

She says now it feels like time is running out since CDFW confirmed its plans to euthanize the mother.

“I cry regularly about it. It’s awful they think the only thing they can do is kill the bear,” Zollinger said. “She’s not the only one doing this. There are six moms in the area we are aware of. What are they going to do? Kill them all? That is ridiculous.”

Zollinger says the BEAR League would rather see the animals relocated and even offered to pay for it.

“It’s not the perfect answer but it’s better than her being dead,” Zollinger said. “You can’t kill your way out of this. That doesn’t solve the problem.”

CBS Sacramento asked CDFW what will happen to ‘Bounce’ the cub if its mother is euthanized.

“The cub will be evaluated if and when we are able to catch it. Our goal was to get the cub into a permitted wildlife rehabilitation facility – to break this generational pattern of human conflict and home invasions – and return it to the wild in the spring when it is big enough and old enough to care for itself and when there are a lot of natural resources on the landscape to support its transition to being a wild bear,” a spokesperson for CDFW responded.

The agency clarified it is not actively setting traps for any bears in this area at this time.

BEAR League advocates disagree with CDFW’s approach and say human error can be at least partly to blame for the “break-ins.”

Zollinger says in several cases their group believes home doors were left unlocked or windows were left open, which allowed the bears easy entry and says they cannot be blamed for searching for food to survive in bear country, where the loss of habitat is threatening their kind.

“We do want people to learn how to coexist with the bears. We do that through education. We want people to wire their homes now,” Zollinger said.

She says electric wiring homes in the Tahoe region, which will administer a non-lethal shock when the bears get too close, is the best way to save the animals and protect property.

They also advocate that Tahoe neighbors keep their doors and windows shut and locked, properly secure and dispose of garbage, clean up fallen fruit from trees in their yards and actively work to scare away any bears near a home so they do not get too comfortable.

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Vegetation fire burns two acres in Mecca

Cynthia White

MECCA, Calif. (KESQ) – CAL FIRE reported a vegetation fire near Avenue 66 and Highway 86 in Mecca that spread to two acres on Wednesday night.

They were called to the area around 10:00 p.m. and requested additional engines after the fire began to spread.

CAL FIRE officials report that no structures were threatened, and did not have immediate information on the containment of the fire.

News Channel 3 sent a crew to the scene, and we will update this story as soon as we have any additional information.

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Vandalism against a Trump banner turns to gunfire at a Nantahala Gorge business

By Elijah Skipper

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    SWAIN COUNTY, North Carolina (WLOS) — What began as vandalism outside a rafting company in the Nantahala Gorge escalated into gunfire, according to the Swain County Sheriff’s Office and the business owner who caught the incident on camera.

On Sept. 6, deputies were dispatched around 5:52 p.m. to the Paddle Inn Rafting Company on Highway 19 West for reports of shots fired. Sheriff Brian Kirkland said a deputy responded but did not see the suspect vehicle at the scene. Days later, investigators became aware of a video of the confrontation that was published on YouTube.

Owner Mark Thomas told News 13 he was watching his CCTV cameras when he saw a Jeep slam on its brakes and back up near his property. He said the driver got out, walked across the road, and tore down a Trump banner belonging to his 87-year-old mother.

“I got it up the screen and I’m like, okay, what’s this clown doing?” Thomas said. “And when he got a grip on it that first time he pulled the sign, I was like, I shouldn’t have waited. I could have saved mom’s sign.”

Thomas said he stepped onto his porch with a rifle but did not aim at the suspect. “I don’t want to kill anybody. My life has got to be in threat. I fired two shots in the air,” he added.

According to Thomas, the man in the Jeep fired back several rounds from the road. At one point, Thomas said he heard at least five or six more shots while he was on the phone with 911.

“Who in the world would be psycho enough to come back to a Trump supporter on a porch with a rifle?” Thomas said.

Despite what happened, Thomas said he is not looking for revenge.

“I don’t want to see him get 20 years in jail, but I want him to have some time to think a mark that he carries with him that reminds him I did some stupid stuff when I was young, and the opportunity to make it right, to live a normal life, be a productive citizen,” Thomas said.

Sheriff Kirkland confirmed to News 13 that the vehicle involved has been identified. “We are currently conducting a criminal investigation regarding this incident,” Kirkland said. “The vehicle involved has been identified, and we are coordinating with multiple law enforcement agencies to effectively bring this investigation to a close.”

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Ice cream shop tests new cocoa as shortage drives up costs

By Maria Sarrouh

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    CHARLOTTETOWN, P.E.I. (CTV Network) — The global cocoa shortage has hit a Prince Edward Island ice-cream shop, jeopardizing a fan favourite.

Holman’s Ice Cream Parlour in Summerside, P.E.I. is testing new cocoa powders after its go-to was taken off the shelves amid a global shortage, owner Daniel Meister says.

The shop has backup batches in the freezer while it searches for the right replacement with similar fat content, pH and colour. Alternatives exist, but some cost up to four times more than before.

“We wouldn’t dare take chocolate ice cream out of the lineup. It’s a very, very popular flavour,” Meister said. “It’s a staple… it’s not really something we can take off the menu.”

Holman’s previously paid $9.99 for 700 grams. Over the last couple of years, that rose to $20. But the shop needs much bigger quantities. One product they’re testing goes for $600 for a 20-kilogram bag. Meister says that bag might cover five or six batches.

“It makes a significant difference in our cost,” he said. “Can we find something that matches the quality that we’re expecting while also not bankrupting ourselves or having to pass on that cost to our customers?”

Holman’s isn’t alone, Meister says. Recently, another business in the area couldn’t find cocoa and posted on social media asking for a supplier. The Holman’s team ran over with a few packages they had in store to tide them over.The math matters even more for small businesses managing their margins. Holman’s raised prices by $1 across the board earlier this year and hopes to keep them steady next.

Cocoa costs have surged since late 2023 due to production challenges in countries including Ghana and the Ivory Coast, which experts link to climate change.

Some companies have cut cocoa-related products altogether, says food expert Sylvain Charlebois, a visiting scholar at McGill University’s Faculty of Agriculture.

“They knew they couldn’t sell some of these products at a higher price, essentially. So, they stopped carrying some of these products,” Charlebois said.

His advice to businesses and manufacturers across the Maritimes and the country is not to rely on a single source. Instead, he said it’s safer to have a few suppliers for important ingredients.

“I wish I could say that there is some good news, but it’s quite problematic,” Charlebois said. “The same is happening with coffee…prices are way up.”

Holman’s is known for making more than 100 handcrafted flavours, with 16 on the daily rotation. The shop says that while some recipes may shift, the standard won’t.

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What Prime Minister Mark Carney’s meeting with Mexico’s president could mean for North American trade

By Judy Trinh

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    OTTAWA (CTV Network) — Prime Minister Mark Carney is embarking on a pivotal meeting with Mexican President Claudia Sheinbaum on Thursday, just as the United States officially launches the process to review the North American trade agreement.

The Office of the U.S. Trade Representative will seek public comments on the Canada-U.S.-Mexico Agreement (CUSMA) over 45 days and has scheduled a public hearing in November.

Public consultation is required by law and is a clear sign that the Trump administration is preparing to renegotiate, not just review, the trilateral agreement, says Eric Miller, president of Rideau Potomac Strategy Group.

“They’re trying to get stakeholders a list of all the things they have concerns about. It doesn’t mean all of them become priorities, but they’re starting with a big list and are going to shrink it down to a smaller list,” said Miller, whose client list includes Canadian exporters.

Under the current agreement, Canada’s trade with the U.S. is 85 per cent tariff free, but that could change when CUSMA expires next June.

“Donald Trump doesn’t have a commitment to a bigger vision of North American collaboration,” Miller said.

Diversifying trade with Mexico

Squeezed by Trump’s sectoral tariffs on steel, aluminum and autos, Canada’s GDP shrunk by 1.6 per cent in the second quarter of 2025.

It’s under this pressure that Carney is meeting with Sheinbaum to strengthen their bilateral relationship and increase trade.

Mexico is Canada’s third biggest trading partner and last year, the two countries did $56 billion in imports and exports.

Foreign Affairs Minister Anita Anand and Minister Dominic LeBlanc, the government’s point person for U.S. trade negotiations, will also be part of the meetings in Mexico City.

Ahead of the prime minister’s 36-hour whirlwind trip, senior government officials told reporters in a briefing that Carney and Sheinbaum will hold one-on-one meetings, followed by a working lunch with their cabinet ministers and secretaries.

A new strategic partnership will be signed that would include commitments for more frequent high-level contact between the two governments.

Other than in June, when Carney met with Sheinbaum on the margins of the G7, the last time there was an official meeting between the leaders of Canada and Mexico without the U.S. was in 2017.

The prime minister will also visit a train terminal to watch Canadian Pacific Railway offload a delivery of Canadian wheat, and host a reception to connect business leaders from both countries.

‘Aligning’ interests Goldy Hyder, CEO of the Business Council of Canada, says the government needs to use the meeting to better position itself for the CUSMA review by working “in tandem with Mexico to align” interests.

Hyder says Canada also needs to pitch itself as an “investment destination” for mining and energy, as well as for developing port infrastructure.

According to John Boscariol, who leads the International Trade and Investment Law Group at McCarthy Tetrault, Canada only represents five per cent of Mexico’s international trade.

As Canada looks to diversify its trade, Boscariol says Mexico is the “natural next best trading partner to the United States.”

Boscariol sees an opportunity for Canada to sell more auto parts to Mexico, along with agricultural products such as potash.

Co-operation vs. competition

But the two countries cannot replace the U.S. with each other.

Duncan Wood, with Washington-based Hurst International Consulting, has researched Mexican trade and supply chains. Wood says as CUSMA negotiations progress, tensions between the two smaller partners could increase.

“I find it very difficult to imagine how the two countries are going to find a lot of common ground. There’s so much pressure right now pushing them away from each other as each one tries to secure preferential treatment from Washington.”

Wood says Carney and Sheinbaum need to discuss aligning their policies on China if they want a stronger position when CUSMA is renegotiated.

“The big thing that matters in Washington is if you can show how Mexico and Canada can help with the United States’ geopolitical competition with China.”

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DP dominates Santa Barbara in boys water polo

Mike Klan

GOLETA, Calif. (KEYT). – Dos Pueblos raced out to a 6-1 lead after the first quarter and never let Santa Barbara in the game as the Chargers won 17-6 in their Channel League opener.

The Dons fell to 0-2 in league.

Grant Nelson scored a game-high 7 goals as DP led 13-3 at halftime and called off the dogs in the second half.

Aracin Marshall dished out 8 assists and freshman Koa Zertuche had 13 saves for the Chargers who improved to 10-2 overall.

Santa Barbara was led by Paolo Borgioli who had 2 goals and 2 assists.

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Coaches talk Big Game as rivals San Marcos and Santa Barbara square off on Friday

Mike Klan

SANTA BARBARA, Calif. (KEYT). – No one is giving San Marcos a chance in Friday’s 65th Annual Big Game at Santa Barbara.

The Royals have heard that before.

Just last year San Marcos, a heavy underdog, shocked the Dons by going toe-to-toe with them.

The game ended in a controversial 20-20 tie, the first deadlock in the history of this series.

The Dons lead the all-time series 39-24-1.

Santa Barbara is 2-2 on the year, San Marcos is 1-3.

“Control the football, control the clock and keep it close, if we do that we have a shot,” said Royals head coach Ralph Molina.

Santa Barbara head coach Nate Mendoza is excited for Friday saying, “This is the one game I remind them(his team) it’s not really about us, it’s about our alumni, our staff, everybody who has worn the helmet before, I take a lot of pride in this game.”

The Big Game is Friday at Peabody Stadium at 7p.m.

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Mother of child raped, beaten arrested; boyfriend already behind bars

By Web Staff

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    SHREVEPORT, Louisiana (KTBS) — The mother of a young child who investigators say was raped and beaten nearly to death last month is now behind bars — along with her boyfriend who was previously accused in the crime.

Caddo Parish sheriff’s investigators arrested Shea Upshaw, 31, Wednesday on charges of accessory after the fact and obstruction of justice. She was arrested in Bossier Parish and booked into the Caddo Correctional Center. No bond is set.

Already in custody is Lucas Logan, 31, of Stonewall. He’s held in CCC on charges of first-degree rape, attempted first-murder, 16 counts of production of pornography involving juveniles and molestation of a juvenile.

Logan was arrested on Aug. 2 after deputies, who responded to a sexual assault complaint, found a nearly lifeless six-year-old child in a home on Farmridge Road in Keithville.

Deputies said the child had been sexually assaulted and suffered what was described as life-threatening injuries.

Logan was identified as the suspect in the child’s injuries.

Upshaw was interviewed multiple times during the investigation. She confessed to lying to protect Lucas, the sheriff’s office said, by cleaning and removing evidence related to the crime.

Caddo District Judge Chris Victory signed an arrest warrant for Upshaw on Sept. 10.

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50,000 pounds of marine debris sorted for science

By Kimber Collins

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    KAILUA, Hawaii (KITV) — Inside a Windward Oʻahu warehouse, piles of trash cover the floor, fishing nets, oyster spacers, toothbrushes, toys, even mannequin heads and duck decoys.

It may look like garbage, but to scientists and volunteers, it’s valuable data.

“We have this incredible team that’s here that is sorting it all out and categorizing it by piece so that we can better understand what it is that shows up on our coastlines,” said Rafael Bergstrom, Sustainable Coastlines Hawaiʻi Executive Director.

Volunteers carefully dump debris, sift through the piles, and place each item into labeled bins. Some items come with unexpected surprises.

Sarah Jeanne Royer with The Ocean Cleanup pointed out a plastic bottle covered in clear bite marks.

“This bottle is really interesting because we can clearly see the bite marks,” Royer said.

Every piece is weighed, recorded, and logged into a global database to help researchers pinpoint the sources of marine debris.

This effort is part of Marine Debris Catch Analysis Volunteer Week, where Sustainable Coastlines Hawaiʻi (SCH) joined forces with The Ocean Cleanup and the Papahānaumokuākea Marine Debris Project (PMDP).

Together, they are processing debris collected from Laysan Island and Kalaupapa.

“It comes from Asia, the Aleutian Islands, Alaska, the Pacific Northwest, even all the way down to the equatorial region,” explained James Morioka, Executive Director of the PMDP.

According to SCH, 60% of the debris comes from commercial fishing vessels. The rest is man-made trash that has drifted across the Pacific.

This batch of debris alone weighed in at 50,000 pounds, but experts warn it’s just a small fraction of what the ocean holds.

“Our lifestyles, our world, is contributing this much plastic to the oceans, which has detrimental effects, from how it affects the animals in the ocean to how it affects us as we breathe in all of this plastic, or ingest the plastic,” Bergstrom said.

Every year, an estimated 115,000 pounds of marine debris accumulate in Papahānaumokuākea, according to Morioka.

“Our goal is to remove two years’ worth, we set our to catch up and keep up essentially. ” he added.

The debris doesn’t just end with cleanup. Researchers analyze the data and publish scientific papers that influence global decision-making.

“Once we analyze everything, this is to understand the main goal: where are these debris coming from, how they’ve been sitting out there. And then the idea is to use that scientific paper to have the large policy makers reading that and designing better laws to stop that pollution from the source,” said Royer.

After analysis, the debris is recycled, repurposed or incinerated, ensuring none of it returns to the ocean.

For Sustainable Coastlines Hawaiʻi, this work builds on a mission years in the making. The nonprofit has already removed more than 750,000 pounds of debris from Hawaiʻi’s shores, reached 55,000 students with educational programs, and mobilized 50,000 volunteers.

While the mountain of debris can feel overwhelming, organizers said efforts like these prove that solutions begin with understanding, and every piece of trash tells a story.

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